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Gibco™ Human TSG Recombinant Protein, PeproTech®

Artikelnummer. 17841183
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Menge:
1 mg
10 μg
100 μg
250 μg
50 μg
500 μg
Packungsgröße:
1 Milligramm
10 Mikrogramm
100 Mikrogramm
250 Mikrogramm
50 Mikrogramm
500 Mikrogramm
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Artikelnummer. 17841183

Marke: Gibco™ 1200950UG

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Beschreibung

Recombinant Protein

Recombinant Human TSG is a 198 amino acid, 22.2 kDa protein containing the BMP/TGF-beta binding portion of the full length TSG protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
TRUSTED_SUSTAINABILITY

Spezifikation

Zugriffsnummer Q9GZX9
Zur Verwendung mit (Anwendung) Functional Assay
Zusammensetzung protein with no preservative
Gen-ID (Entrez) 57045
Molekulargewicht 22.2 kDa
Name Human TSG
Menge 50 μg
Quelle E. coli
Kennzeichnung RUO
Endotoxin-Konzentration <1 EU/ μg
Gen-Alias 1810013J15Rik; 9030422N06Rik; AW552143; D17Ertd403e; PSEC0250; Tsg; Twg; twisted gastrulation BMP signaling modulator 1; twisted gastrulation homolog 1; twisted gastrulation homolog 1 (Drosophila); twisted gastrulation protein homolog 1; Twsg1
Gebräuchliche Bezeichnung TSG
Gensymbol Twsg1
Biologische Aktivität Determined by its ability to neutralize BMP-6-induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is ≤ 2.0 ug/ml of TSG.
Konjugat Unconjugated
Rekombinant Recombinant
Sequenz CNKALCASDV SKCLIQELCQ CRPGEGNCSC CKECMLCLGA LWDECCDCVG MCNPRNYSDT PPTSKSTVEE LHEPIPSLFR ALTEGDTQLN WNIVSFPVAE ELSHHENLVS FLETVNQPHH QNVSVPSNNV HAPYSSDKEH MCTVVYFDDC MSIHQCKISC ESMGASKYRW FHNACCECIG PECIDYGSKT VKCMNCMF
Inhalt und Lagerung -20°C
Expressionssystem E. coli
Form Lyophilized
Reinheits- oder Qualitätsgrad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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