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Invitrogen™ IL23R Recombinant Rabbit Monoclonal Antibody (3Y7B9)
Rabbit Recombinant Monoclonal Antibody
Marke: Invitrogen™ MA558205
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Beschreibung
Immunogen sequence: GITSINCSGD MWVEPGEIFQ MGMNVSIYCQ EALKHCRPRN LYFYKNGFKE EFDITRINRT TARIWYKGFS EPHAYMHCTA ECPGHFQETL ICGKDISSGH PPDAPSNLTC VIYEYSGNMT CTWNTGKPTY IDTKYIVHVK SLETEEEQQY LASSYVKIST DSLQGSRKYL VWVQAVNSLG MENSQQLHVH LDDIVIPSAS IISRAETTND TVPKTIVYWK SKTMIEKVFC EMRYKTTTNQ TWSVKEFDAN FTYVQ.
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
Spezifikation
| IL23R | |
| Recombinant Monoclonal | |
| 0.22 mg/mL | |
| PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3 | |
| Q8K4B4 | |
| Il23r | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 24-315 of mouse IL-23R (NP_653131.3). | |
| 20 μL | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
| ELISA, Western Blot | |
| 3Y7B9 | |
| Unconjugated | |
| Il23r | |
| IBD17; IL 23R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin 23 receptor-like; interleukin-23 receptor | |
| Rabbit | |
| Protein A | |
| RUO | |
| 209590 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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