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Indomethacin, 99+%

Artikelnummer. 15425529
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Artikelnummer. 15425529 Lieferant Thermo Scientific Alfa Aesar Lieferanten-Nr. J63255.03
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Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen
Regulatorischer Hinweis: Abgabe sachkundepflichtiger Stoffe und Gemische nur bei Erfüllung der Vorrausetzungen nach Chemikalienverbotsverordnung (ChemVerbotsV). Keine Abgabe an Privatpersonen.

Beschreibung

Indometacin, CAS-r. 53-86-1, ist ein indolbasierter nichtsteroidaler Entzündungshemmer (NSAID).

Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release
  • Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics
  • Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

  • Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions
  • Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 53-86-1
Summenformel C19H16ClNO4
Molekulargewicht (g/mol) 357.79
MDL-Nummer MFCD00057095
InChI-Schlüssel CGIGDMFJXJATDK-UHFFFAOYSA-N
Synonym indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
PubChem CID 3715
ChEBI CHEBI:49662
IUPAC-Name 2-[1-(4-Chlorbenzoyl)-5-Methoxy-2-Methylindol-3-yl]Ethansäure
SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Specifications

Chemischer Name oder Material Indomethacin
Schmelzpunkt 158°C to 161°C
Farbe Weiß
Menge 1 g
UN-Nummer UN2811
Beilstein 497341
Empfindlichkeit Lichtempfindlich
Merck Index 14,4968
Löslichkeitsinformationen Soluble in ethanol and dimethyl sulfoxide.
Formelmasse 357.8
Reinheit (%) ≥99%
Physikalische Form Pulver
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