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Invitrogen™ IRAK4 Monoclonal Antibody (413609)
Rat Monoclonal Antibody
Marke: Invitrogen™ MA561360
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Beschreibung
Reconstitute at 0.5 mg/mL in sterile PBS.
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
Spezifikation
| IRAK4 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| Q9NWZ3 | |
| IRAK4 | |
| E. coli-derived recombinant human IRAK4, Met1-Ser460. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin) | |
| 413609 | |
| Unconjugated | |
| IRAK4 | |
| 8430405M07Rik; 9330209D03Rik; interleukin 1 receptor associated kinase 4; interleukin-1; interleukin-1 receptor-associated kinase 4; IPD1; Irak4; IRAK-4; NY-REN-64; REN64; renal carcinoma antigen NY-REN-64 | |
| Rat | |
| Protein A/G | |
| RUO | |
| 51135 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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