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Invitrogen™ ITGA4 Monoclonal Antibody (Bu49)
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Artikelnummer. 11530013
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Menge:
200 μg
Packungsgröße:
200 Mikrogramm
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11530013 200 μg 200 Mikrogramm
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Artikelnummer. 11530013 Lieferant Invitrogen™ Lieferanten-Nr. MA181535

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Beschreibung

Mouse Monoclonal Antibody

The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. We recommend the use of acetone fixation for frozen sections. A suggested positive control for immunohistochemical applications is human tonsil. For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Mouse anti Human CD49d monoclonal antibody, clone Bu49 recognizes human CD49d, also known as integrin alpha 4 or VLA-4 alpha subunit. CD49d is a approximately 150 kDa single pass type I transmembrane glycoprotein.

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen ITGA4
Anwendungen Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
Klassifikation Monoclonal
Klon Bu49
Konzentration 1 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 0.09% sodium azide; pH 7.4
Gen ITGA4
Gen-Zugriffsnummer P13612
Gen-Alias 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; IA4; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin subunit alpha 4; integrin, alpha 4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); Itga4; Itga4B; ITGA-IV; LPAM subunit alpha; lymphocyte Peyer patch adhesion molecules subunit alpha; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Gensymbole ITGA4
Wirtsspezies Mouse
Immunogen Hyatt myeloma cell line.
Reinigungsverfahren Protein A
Menge 200 μg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 3676, 488429
Zielspezies Human, Canine
Inhalt und Lagerung Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Produkttyp Antibody
Form Liquid
Isotype IgG1
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