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Kaempferol, 98+ %, Thermo Scientific Chemicals

Product Code. 15443159
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Product Code. 15443159 Supplier Thermo Scientific Alfa Aesar Supplier No. J60373.MF
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Description

CAS: 520-18-3 | Molecular Formula: C15H10O6 | Molecular Weight: 286.24 g/mol

Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Anwendungen
Kaempferol, wird als Inhibitor der Fettsäure-Synthase, Cox-1 Aktivität und Topo I.verwendet. Induziert auch Caspase-9-vermittelte Apoptose in einer Vielzahl von Krebszelllinien durch die Herabregulation polo-ähnlicher Kinase-1-(PLK1)-Expression. Zeigt antioxidative Aktivität und dämpft die osteoklastische Knochenresorption in vitro. Blockiert auch EGF-induzierte Histon-H3Ser10-Phosphorylierung in mausepidermalen JB6-C141-Zellen.

Löslichkeit
Löslich in DMSO oder Ethanol zu 100 mM

Hinweise
Kühl lagern. Behälter an einem trockenen und gut belüfteten Ort dicht verschlossen halten. Lichtempfindlich. Von starken Oxidationsmitteln fernhalten.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 520-18-3
Summenformel C15H10O6
Molekulargewicht (g/mol) 286.24
MDL-Nummer MFCD00016938
InChI-Schlüssel IYRMWMYZSQPJKC-UHFFFAOYSA-N
Synonym kaempferol, kaempherol, kempferol, populnetin, rhamnolutein, robigenin, trifolitin, pelargidenolon, rhamnolutin, swartziol
PubChem CID 5280863
ChEBI CHEBI:28499
SMILES OC1=CC=C(C=C1)C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1

Specifications

Chemischer Name oder Material Kaempferol
Schmelzpunkt 276°C to 278°C
Farbe Gelb
Menge 50 mg
Beilstein 304401
Merck Index 14,5274
Löslichkeitsinformationen Soluble in DMSO or ethanol to 100mM
IUPAC-Name 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)chromen-4-on
Formelmasse 286.24
Reinheit (%) ≥98%
Physikalische Form Pulver
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