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KN-62, Thermo Scientific Chemicals

Catalog Number p-7042411
Click to view available options
Menge:
1 mg
10 mg
Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen
127191-97-3
C38H35N5O6S2
721.85
MFCD00083180
RJVLFQBBRSMWHX-UHFFFAOYNA-N
s-4-2-n-methylisoquinoline-5-sulfonamido-3-oxo-3-4-phenylpiperazin-1-yl propyl phenyl isoquinoline-5-sulfonate, unii-63hm46xpow, chembl28324, 63hm46xpow, 1-n,o-bis 5-isoquinolinesulfonyl-n-methyl-l-tyrosyl-4-phenylpiperazine, s-5-isoquinolinesulfonic acid 4-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl ester, 4-2s-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl isoquinolinesulfonic acid ester, 4-2s-2-n-methylisoquinoline-5-sulfonamido-3-oxo-3-4-phenylpiperazin-1-yl propyl phenyl isoquinoline-5-sulfonate, 5-isoquinolinesulfonic acid, 4-2s-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl ester
5312126
4-[2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl isoquinoline-5-sulfonate
CN(C(CC1=CC=C(OS(=O)(=O)C2=C3C=CN=CC3=CC=C2)C=C1)C(=O)N1CCN(CC1)C1=CC=CC=C1)S(=O)(=O)C1=C2C=CN=CC2=CC=C1
Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen
127191-97-3
C38H35N5O6S2
721.85
MFCD00083180
RJVLFQBBRSMWHX-UHFFFAOYNA-N
s-4-2-n-methylisoquinoline-5-sulfonamido-3-oxo-3-4-phenylpiperazin-1-yl propyl phenyl isoquinoline-5-sulfonate, unii-63hm46xpow, chembl28324, 63hm46xpow, 1-n,o-bis 5-isoquinolinesulfonyl-n-methyl-l-tyrosyl-4-phenylpiperazine, s-5-isoquinolinesulfonic acid 4-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl ester, 4-2s-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl isoquinolinesulfonic acid ester, 4-2s-2-n-methylisoquinoline-5-sulfonamido-3-oxo-3-4-phenylpiperazin-1-yl propyl phenyl isoquinoline-5-sulfonate, 5-isoquinolinesulfonic acid, 4-2s-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl ester
5312126
4-[2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl isoquinoline-5-sulfonate
CN(C(CC1=CC=C(OS(=O)(=O)C2=C3C=CN=CC3=CC=C2)C=C1)C(=O)N1CCN(CC1)C1=CC=CC=C1)S(=O)(=O)C1=C2C=CN=CC2=CC=C1

Hemmt stark spezifisch die Calcium/Calmodulinkinase II

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Anwendungen
Es wird als starker und selektiver Inhibitor von CaMKII verwendet. KN-62 hat eine starke und selektive Hemmung der Ca2+/Calmodulin-abhängigen Proteinkinase II (CaMKII; Ki=,9 μM) nachgewiesen, die dazu führt, dass Zellen in der S-Phase blockieren. In HEK-293-Zellen, die Adenylcyclase vom Typ III (III-AC) exprimieren, blockierte 10 μM von KN-62 die CaMKII-Phosphorylation von III-AC und hemmte hormonstimulierte Ca2+-Schwingungen. Außerdem ist KN-62 ein potenter nicht-kompetitiver Antagonist am P2X7-Rezeptor (IC50 = 15 nM).

Löslichkeit
Löslich in 45 % (w/v) aq 2-Hydroxypropyl-β-Cyclodextrin (0,93 mg/ml), Methanol (10 mg/ml), DMSO (12 mg/ml), Chloroform (20 mg/ml), Ethanol (∼1 mg/ml), 1:2 DMF:PBS (pH 7,2) (∼0,3 mg/ml) und DMF & DMSO (∼30 mg/ml).

Hinweise
An einem kühlen Ort aufbewahren. Behälter an einem trockenen und gut belüfteten Ort dicht verschlossen halten. Empfohlene Lagertemperatur: -20 °C. Von starken Oxidationsmitteln fernhalten.
TRUSTED_SUSTAINABILITY
Chemischer Name oder Material KN-62
Schmelzpunkt 65°C to 67°C
Farbe Gelb
Strukturformel NH2(CH2)10NH2
Menge 1 mg
Löslichkeitsinformationen Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.93mg/ml),methanol (10mg/ml),DMSO (12mg/ml),chloroform (20mg/ml),ethanol (∽1mg/ml),1:2 DMF:PBS (pH 7.2) (∽0.3mg/ml),and DMF & DMSO (∽30mg/ml).
Formelmasse 721.84
Physikalische Form Pulver

RUO – Research Use Only

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