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Invitrogen™ LAT Polyclonal Antibody
Sheep Polyclonal Antibody
Marke: Invitrogen™ PA5149153
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Beschreibung
Reconstitute at 0.2 mg/mL in sterile PBS.
LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
Spezifikation
| LAT | |
| Polyclonal | |
| Unconjugated | |
| LAT | |
| 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; Lat; LAT1; linker for activation of T cells; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells; linker for activation of T-cells family member 1; linker protein; p36-38; pp36 | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 27040 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| O43561 | |
| LAT | |
| E. coli-derived recombinant human LAT, His30-Glu113. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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