Invitrogen™ Lewis Y Biosimilar Recombinant Monoclonal Antibody

The Lewis Y (Le^y) gene is not actually a single gene but refers to a carbohydrate antigen known as Lewis Y or Le^y antigen, which is part of the Lewis blood group system. This antigen is synthesized by the fucosylation of precursor substances, which involves enzymes encoded by the FUT1 (fucosyltransferase 1) and FUT2 genes. These genes are responsible for the addition of fucose, a hexose deoxy sugar, to the precursor oligosaccharides. The expression of Lewis Y antigen has been extensively studied in the context of cancer biology as it is commonly found on the surface of epithelial and endothelial cells but overexpressed in various types of cancers, including colorectal, gastric, and ovarian carcinomas. The overexpression and altered glycosylation patterns of Le^y antigen in tumors have made it a potential biomarker for cancer diagnosis and a target for immunotherapeutic approaches.