Invitrogen™ LRP1 Cluster III Polyclonal Antibody

Beschreibung

Reconstitute at 0.2 mg/mL in sterile PBS.

LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Cluster III is a specific domain within the LRP1 gene, which encodes a large endocytic receptor involved in various physiological processes, including lipid metabolism, signal transduction, and cellular homeostasis. LRP1 is a multifunctional receptor that binds and internalizes a wide range of ligands, including lipoproteins, proteases, and extracellular matrix proteins. Cluster III of LRP1 is one of its four ligand-binding domains and plays a crucial role in mediating interactions with specific ligands, thereby influencing receptor function. This domain is important for the clearance of amyloid-beta in the brain, which is relevant to Alzheimer's disease, as well as for the regulation of protease activity and the modulation of cell signaling pathways that impact cell migration, proliferation, and survival. Dysregulation or mutations in LRP1, including its Cluster III domain, have been implicated in various diseases, such as cardiovascular disorders, neurodegenerative diseases, and certain cancers. Understanding the structure and function of LRP1 Cluster III is essential for developing targeted therapeutic strategies aimed at modulating its activity to treat related diseases. Research into LRP1 Cluster III provides valuable insights into the receptor's diverse roles in health and disease and its potential as a therapeutic target.