Invitrogen™ NGAL Monoclonal Antibody (14)

Beschreibung

ABS 047-14-02 binds free canine NGAL. This antibody shows no cross-reaction with human, mouse ,or rat. ABS 047-14-02 can be used as a capture antibody in a sandwich ELISA using biotinylated detection antibody ABS 047-17-02, giving a detection limit of 5 pg/mL in an unoptimized buffer assay. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

NGAL (Neutrophil gelatinase-associated lipocalin, lipocalin 2, siderocalin and neutrophil lipocalin) is a 25 kDa glycosylated single chain monomer and member of the lipocalin family of proteins that bind and transport small lipophilic molecules. NGAL is released by activated neutrophils, can form dimers and small amounts of higher oligomers, and complexes with matrix metalloproteinase 9 (MMP-9, gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by ischemic or nephrotoxic kidney injury.