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Invitrogen™ NOD3 Polyclonal Antibody
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Artikelnummer. 17157143
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Menge:
100 μL
Packungsgröße:
100 Mikroliter
Artikelnummer. Menge unitSize
17157143 100 μL 100 Mikroliter
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Artikelnummer. 17157143

Marke: Invitrogen™ PA5109210

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Description

Rabbit Polyclonal Antibody

Positive Control: MCF-7, SH-SY5Y, human tonsil tissue, human colon cancer tissue, human spleen tissue, mouse colon tissue.

NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOD3
Anwendungen Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
Klassifikation Polyclonal
Konzentration 1 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gen NLRC3
Gen-Zugriffsnummer Q7RTR2
Gen-Alias CARD15-like protein; caterpillar 16.2; Caterpiller 16.2; caterpiller protein 16.2; CLR16.2; D230007K08Rik; mFLJ00348; NACHT, LRR and CARD domains-containing protein 3; NLR family CARD domain containing 3; NLR family CARD domain-containing protein 3; NLR family, CARD domain containing 3; NLR family, CARD domain containing 3, pseudogene 1; Nlrc3; Nlrc3-ps1; NOD3; NOD-like receptor C3; Nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; protein NLRC3; RGD1304902
Gensymbole NLRC3
Wirtsspezies Rabbit
Immunogen Synthetic peptide within Human NLRC3 aa 985-1,034.
Reinigungsverfahren Affinity chromatography
Menge 100 μL
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 197358
Zielspezies Human
Inhalt und Lagerung -20°C, Avoid Freeze/Thaw Cycles, store in dark
Produkttyp Antibody
Form Liquid
Isotype IgG
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