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Invitrogen™ NOD3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marke: Invitrogen™ PA5109210
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Beschreibung
Positive Control: Human thymus tissue lysates, HUVEC, MCF-7, SH-SY5Y, human tonsil tissue, human colon cancer tissue, human spleen tissue, mouse colon tissue.
NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
Spezifikation
| NOD3 | |
| Polyclonal | |
| Unconjugated | |
| NLRC3 | |
| CARD15-like protein; caterpillar 16.2; Caterpiller 16.2; caterpiller protein 16.2; CLR16.2; D230007K08Rik; mFLJ00348; NACHT, LRR and CARD domains-containing protein 3; NLR family CARD domain containing 3; NLR family CARD domain-containing protein 3; NLR family, CARD domain containing 3; NLR family, CARD domain containing 3, pseudogene 1; Nlrc3; Nlrc3-ps1; NOD3; NOD-like receptor C3; Nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; protein NLRC3; RGD1304902 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 197358 | |
| -20°C, Avoid Freeze/Thaw Cycles, store in dark | |
| Liquid |
| Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4 | |
| Q7RTR2 | |
| NLRC3 | |
| Synthetic peptide within Human NLRC3 aa 985-1,034. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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