Invitrogen™ NOTCH3 Recombinant Rabbit Monoclonal Antibody (1A7L4)

Beschreibung

Immunogen sequence: PAAGAHSSPP KARFLRVPSE HPYLTPSPES PEHWASPSPP SLSDWSESTP SPATATGAMA TTTGALPAQP LPLSVPSSLA QAQTQLGPQP EVTPKRQVLA.

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).