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Invitrogen™ NUMB Monoclonal Antibody (447716)
Mouse Monoclonal Antibody
Marke: Invitrogen™ MA561422
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Beschreibung
Reconstitute at 0.5 mg/mL in sterile PBS.
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
Spezifikation
| NUMB | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| P49757 | |
| Numb | |
| E. coli-derived recombinant human Numb, Thr356-Leu592. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Western Blot, Immunocytochemistry | |
| 447716 | |
| Unconjugated | |
| Numb | |
| c14_5527; C14orf41; h-Numb; mnb; m-Nb; m-numb; Nb; NUMB; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila); NUMB isoform 3; Numb variant 1; Numb variant 2; NUMB, endocytic adaptor protein; protein numb homolog; Protein S171; PTB domain protein; S171 | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 8650 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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