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  5. Tocris Bioscience™ Omipalisib

Tocris Bioscience™ Omipalisib
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Artikelnummer. 18715696
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Menge:
10 mg
50 mg
Unit Size:
10 Milligramm
50 Milligramm
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Product Code. 18715696

Brand: Tocris Bioscience™ 6792/10

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Description

Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK

Omipalisib is a highly potent PI 3-K inhibitor (IC50 = 0.04 nM). Also inhibits mTOR (Ki = 0.18 - 0.3 nM) and DNA-PK (IC50 = 0.28 nM). Induces G1 cell cycle arrest and inhibits proliferation of some breast cancer cells lines in vitro. Reduces pAKT-S473 levels in and inhibits growth of BT474 breast cancer xenografts in mice. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemischer Name oder Material 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
Synonym GSK2126458
Menge 10 mg
Summenformel C25H17F2N5O3S
Formelmasse 505.5
Produkttyp Hemmstoff
Reinheit 98%
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