Invitrogen™ PD-L1/VEGF Biosimilar Recombinant Human Monoclonal Antibody

Beschreibung

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °. This antibody can also be cross referenced by the term Pm8002.

The PD-L1 (Programmed Death-Ligand 1) gene, located on chromosome 9p24.1, is essential for immune response modulation and evasion by cancer cells. It encodes a protein comprising extracellular IgV and IgC domains, a transmembrane domain, and a short cytoplasmic tail. PD-L1 binds to the PD-1 receptor on T cells, inhibiting their activity to allow tumor cells to evade immune detection. PD-L1 expression is regulated at multiple levels: genetic, epigenetic, transcriptional, and post-transcriptional. Similarly, VEGF (Vascular Endothelial Growth Factor) is a critical regulator of angiogenesis and vasculogenesis, located on chromosome 6p21.1. VEGF-A, the most studied isoform, promotes endothelial cell proliferation, migration, and survival, primarily through binding to VEGFR1 and VEGFR2 receptors. VEGF is pivotal in both physiological processes like wound healing and pathological conditions such as cancer, where it facilitates tumor growth by enhancing blood supply.