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Description
PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
Spécification
Spécification
| Antigen | PHLPP |
| Anwendungen | Immunocytochemistry, Immunoprecipitation, Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin) |
| Klassifikation | Polyclonal |
| Konzentration | 0.57 mg/mL |
| Konjugat | Unconjugated |
| Zusammensetzung | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gen | PHLPP1 |
| Gen-Zugriffsnummer | O60346, Q8CHE4 |
| Gen-Alias | hSCOP, KIAA0606, PHLPP, PHLPP1, PLEKHE1, SCOP |
| Gensymbole | Phlpp1 |
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Nom du produit
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