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Invitrogen™ Phospho-FADD (Ser194) Monoclonal Antibody (709736)
Mouse Monoclonal Antibody
Marke: Invitrogen™ MA561759
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Beschreibung
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Spezifikation
| Phospho-FADD (Ser194) | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| Q13158 | |
| FADD | |
| Phosphopeptide containing the human FADD S194 site. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Western Blot, Immunocytochemistry | |
| 709736 | |
| Unconjugated | |
| FADD | |
| Fadd; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Mort1/FADD; protein FADD | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 8772 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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