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Invitrogen™ Phospho-p130 (Thr986) Recombinant Rabbit Monoclonal Antibody (24GB970)
Rabbit Recombinant Monoclonal Antibody
Marke: Invitrogen™ MA557162
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Beschreibung
Phospho-p130 (Thr986) Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
Spezifikation
| Phospho-p130 (Thr986) | |
| Recombinant Monoclonal | |
| 2 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| O55081, Q08999, Q64700 | |
| RBL2 | |
| A synthesized peptide derived from human Phospho-p130 (Thr986) (aa 979-993). | |
| 20 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 24GB970 | |
| Unconjugated | |
| RBL2 | |
| 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 19651, 5934, 81758 | |
| -20°C | |
| Liquid |
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