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Invitrogen™ Phospho-Rb (Ser612) Polyclonal Antibody
Rabbit Polyclonal Antibody
Marke: Invitrogen™ PA5105797
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Beschreibung
Antibody detects endogenous levels of Retinoblastoma only when phosphorylated at Ser612.
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
Spezifikation
| Phospho-Rb (Ser612) | |
| Polyclonal | |
| Unconjugated | |
| RB1 | |
| Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p104; p104 chicken Rb; P105RB; p105-Rb; Phospho-Retinoblastoma; pp105; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; rb; RB transcriptional corepressor 1; RB1; Rb-1; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma 1 (including osteosarcoma); retinoblastoma 1 protein; retinoblastoma gene; retinoblastoma isoform A; retinoblastoma protein; retinoblastoma suspectibility protein; retinoblastoma tumor suppressor; retinoblastoma-associated protein | |
| Rabbit | |
| sequential chromatography | |
| RUO | |
| 19645, 5925 | |
| -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P06400, P13405 | |
| RB1 | |
| A synthesized peptide derived from human RB1(Accession P06400), corresponding to amino acid residues around phosphorylated Ser612. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Monkey | |
| Antibody | |
| IgG |
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