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Invitrogen™ POT1 Monoclonal Antibody (688923)
Mouse Monoclonal Antibody
Marke: Invitrogen™ MA561544
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Beschreibung
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. It binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Its activity is TERT dependent but it does not increase TERT activity.
Spezifikation
| POT1 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| Q9NUX5 | |
| POT1 | |
| E. coli-derived recombinant human POT1, Met159-Pro316. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Western Blot | |
| 688923 | |
| Unconjugated | |
| POT1 | |
| 1500031H18Rik; AI505244; AI851169; CMM10; DKFZp586D211; Dolichyl-phosphate-mannose--protein mannosyltransferase 1; GLM9; HPOT1; mPot1; Pomt1; POT 1; POT1; POT-1; Pot1a; POT1-like telomere end-binding protein; protection of telomeres 1; protection of telomeres 1 homolog; protection of telomeres 1A; protection of telomeres protein 1; protein O-mannosyltransferase 1; Protein O-mannosyl-transferase 1; protein-O-mannosyltransferase 1 | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 25913 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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