R&D Systems™ Quantikine Immunoassay Control Set 925 Human Vitamin D BP

Vitamin D binding protein (VitD BP), also known as DBP and Gc-globulin, is 58 kDa glycoprotein that circulates at high concentration in serum and serves as carrier protein for vitamin D. The transport of vitamin D by VitD BP is important for function of wide variety of tissues. VitD BP binds both 25(OH) and hormonally active 1,25(OH)2 forms of vitamin D. VitD BP is primarily expressed in hepatocytes and to lesser extent in kidney. It delivers vitamin D into cells by Megalin-mediated endocytosis. A selectively deglycosylated form of VitD BP known as macrophage activating factor (MAF) blocks angiogenic effects of FGF basic, VEGF, and Angiopoietin 2. VitD BP enhances chemotaxis of monocytes and neutrophils to activated complement component C5a or C5a des Arg (a C-terminally processed form of C5a). The chemotactic cofactor property of VitD BP is eliminated by binding to 1,25(OH)2 vitamin D, but it is not altered by binding to 25(OH) vitamin D or actin.

• Storage: Store unopened product at 2 to 8°C. Do not use past expiration date.