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Invitrogen™ RAP80 Recombinant Rabbit Monoclonal Antibody (24GB4080)
Beschreibung
RAP80 Recombinant Monoclonal Antibody for Western Blot, ICC/IF
RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
Spezifikation
Spezifikation
| Antigen | RAP80 |
| Anwendungen | Western Blot, Immunocytochemistry |
| Klassifikation | Recombinant Monoclonal |
| Klon | 24GB4080 |
| Konjugat | Unconjugated |
| Zusammensetzung | PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 |
| Gen | UIMC1 |
| Gen-Zugriffsnummer | Q96RL1 |
| Gen-Alias | 9430016E08Rik; BRCA1-A complex subunit RAP80; D330018D10Rik; D630032M02Rik; RAP80; Receptor-associated protein 80; retinoid X receptor interacting protein 110; retinoid X receptor-interacting protein 110; RGD1307009; RIP110; Rxrip110; ubiquitin interaction motif containing 1; ubiquitin interaction motif-containing protein 1; Uimc1; X2HRIP110 |
| Gensymbole | UIMC1 |
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