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Invitrogen™ RNF2 Recombinant Rabbit Monoclonal Antibody (24GB5455)
Rabbit Recombinant Monoclonal Antibody
Marke: Invitrogen™ MA557696
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Beschreibung
RNF2 Recombinant Monoclonal Antibody for Western Blot, Flow
RNF2 (E3 ubiquitin-protein ligase RING2) is a ligase that mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub). Therefore, it plays a central role in histone code and gene regulation. The ligase activity is enhanced by BMI1/PCGF4. H2AK119Ub gives a specific tag for epigeneti transcriptional repression and participates in X chromosome inactivation of female mammals. RNF2 may be involved in the initiation of both imprinted and random X inactivation. RNF2 is also an essential component of a Polycomb group (PcG) multiprotein PRC1-like complex. This complex class is required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones and rendering chromatin heritably changed in its expressibility.
Spezifikation
| RNF2 | |
| Recombinant Monoclonal | |
| Unconjugated | |
| RNF2 | |
| AI326319; AI450156; AU019207; BAP 1; BAP1; BAP-1; DinG; DinG protein; E3 ubiquitin-protein ligase RING2; fa19h05; GS1-120K12.1; HIP2-interacting protein 3; HIPI 3; HIPI3; Huntingtin-interacting protein 2-interacting protein 3; OTTHUMP00000060668; protein DinG; RING 1B; RING 2; RING finger protein 1B; ring finger protein 2; RING finger protein BAP-1; RING1B; RING2; RING-type E3 ubiquitin transferase RING2; RNF 2; Rnf2; wu:fa19h05; wz4556; wz4566 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 19821, 304850, 6045 | |
| -20°C | |
| Liquid |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 24GB5455 | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q4KLY4, Q99496, Q9CQJ4 | |
| RNF2 | |
| A synthesized peptide derived from human RING2 / RING1B / RNF2 (aa 118-131). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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