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Invitrogen™ Ryanodine Receptor Monoclonal Antibody (C3-33)
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Artikelnummer. 11505802
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Menge:
100 μg
Packungsgröße:
100 Mikrogramm
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11505802 100 μg 100 Mikrogramm
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Artikelnummer. 11505802 Lieferant Invitrogen™ Lieferanten-Nr. MA3916

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Beschreibung

Mouse Monoclonal Antibody

MA3-916 detects ryanodine receptor 2 (RyR2) and shows cross-reactivity with RyR1 in amphibian, canine, chicken, fish, guinea pig and rat tissues. MA3-916 has been successfully used in Western blot, immunohistochemical, immunofluorescence, immunocytochemistry and immunoprecipitation procedures. By Western blot, this antibody detects a 565 kDa protein representing the ryanodine receptor. In non-mammalian vertebrates, a doublet is seen at 565 kDa representing the alpha and beta isoforms of the receptor. Immunohistochemical staining of RyR in rat cardiac tissue with MA3-916 results in intense staining of the myofiber, which is consistent with sarcoplasmic reticulum localization.

The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the 'foot' region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen Ryanodine Receptor
Anwendungen Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Klassifikation Monoclonal
Klon C3-33
Konzentration 1 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 0.05% sodium azide
Gen RYR1
Gen-Zugriffsnummer B0LPN4, E9PZQ0, E9Q401, F1LMY4, P11716, P21817, P30957, Q92736
Gen-Alias 9330127I20Rik; AI528790; ARVC2; ARVD2; Ca2+ release channel; calcium release channel; cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; cardiac muscle-type ryanodine receptor; cardiac ryanodine receptor; cardiac ryanodine receptor 2; cardiac-type ryanodine receptor; CCO; central core disease of muscle; islet-type ryanodine receptor; kidney-type ryanodine receptor; LOW QUALITY PROTEIN: ryanodine receptor 1; MHS; MHS1; PPP1R137; protein phosphatase 1, regulatory subunit 137; ryanodine receptor; ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like, skeletal muscle; ryanodine receptor 2; ryanodine receptor 2 (cardiac); ryanodine receptor 2, cardiac; ryanodine receptor type 2; ryanodine receptor type II; RYDR; Ryr; RYR1; RYR-1; Ryr1l; Ryr2; RYR-2; sarcoplasmic reticulum calcium release channel; skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; SKRR; Type 1 ryanodine receptor; type 1-like ryanodine receptor; type 2 ryanodine receptor; unnamed protein product; VTSIP
Gensymbole RYR1, RYR2
Wirtsspezies Mouse
Immunogen Canine cardiac ryanodine receptor (RyR2).
Reinigungsverfahren Protein G
Menge 100 μg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 100009536, 100009540, 100727848, 100731307, 114207, 20190, 20191, 396112, 403615, 421508, 606491, 6261, 6262, 689560
Zielspezies Amphibian, Canine, Chicken, Fish, Guinea Pig, Human, Mouse, Rabbit, Rat
Inhalt und Lagerung -20°C, Avoid Freeze/Thaw Cycles
Produkttyp Antibody
Form Liquid
Isotype IgG1
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