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Invitrogen™ SARS-CoV-2 NSP1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marke: Invitrogen™ PA5116941
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Beschreibung
Positive Samples: 293T Immunogen sequence: MESLVPGFNE KTHVQLSLPV LQVRDVLVRG FGDSVEEVLS EARQHLKDGT CGLVEVEKGV LPQLEQPYVF IKRSDARTAP HGHVMVELVA ELEGIQYGRS GETLGVLVPH VGEIPVAYRK VLLRKNGNKG AGGHSYGADL KSFDLGDELG TDPYEDFQEN WNTKHSSGVT RELMRELNGG.
Inhibits host translation by interacting with the 40S ribosomal subunit (PubMed:32680882). Nsp1 C terminus binds to and obstructs ribosomal mRNA entry tunnel (PubMed:32680882). Thereby inhibits antiviral response triggered by innate immunity or interferons (PubMed:32680882). The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
Spezifikation
| SARS-CoV-2 NSP1 | |
| Polyclonal | |
| Unconjugated | |
| COVID19 Nsp1; COVID-19 Nsp1; SARS-CoV-2 Nonstructural Protein 1; SARS-CoV2 NSP1; SARS-COV-2 NSP1 | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of coronavirus NSP1 (YP_0097426081). | |
| 100 μL | |
| Primary | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Immunoprecipitation, Western Blot | |
| 1.15 mg/mL | |
| PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| Virus | |
| Antibody | |
| IgG |
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