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Invitrogen™ SMO Monoclonal Antibody (1015418)
Mouse Monoclonal Antibody
Marke: Invitrogen™ MA560873
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Beschreibung
Reconstitute at 0.5 mg/mL in sterile PBS.
Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.
Spezifikation
| SMO | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 5% trehalose and no preservative | |
| Q99835 | |
| SMO | |
| Chinese Hamster Ovary cell line, CHO-derived human Smoothened, Met1-Tyr233. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Immunohistochemistry (Paraffin) | |
| 1015418 | |
| Unconjugated | |
| SMO | |
| bent body; bnb; E130215L21Rik; frizzled family member 11; FZD11; Gx; HGNC:11119; Protein Gx; Protein SMOH; seven transmembrane helix receptor; SMO; SMOH; smoothened; Smoothened homolog; smoothened homolog (Drosophila); smoothened, frizzled class receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 6608 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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