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Invitrogen™ SP1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marke: Invitrogen™ PA529165
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Beschreibung
Recommended positive controls: 293T, K562, THP-1, HL-60, Raji. Predicted reactivity: Mouse (96%), Rat (99%), Rhesus Monkey (99%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Spezifikation
| SP1 | |
| Polyclonal | |
| Unconjugated | |
| SP1 | |
| 1110003E12Rik; AA450830; AI845540; HGNC:11205; SP1; Sp1 transcription factor; Sp1-1; specificity protein 1; trans-acting transcription factor 1; transcription factor Sp1; TSFP1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 6667 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 0.88 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
| P08047 | |
| SP1 | |
| Recombinant protein encompassing a sequence within the center region of human SP1. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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