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Invitrogen™ SP1 Polyclonal Antibody

Rabbit Polyclonal Antibody
Marke: Invitrogen™ PA5115954
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Beschreibung
Antibody detects endogenous levels of total SP1.
SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Spezifikation
| SP1 | |
| Polyclonal | |
| Unconjugated | |
| SP1 | |
| 1110003E12Rik; AA450830; AI845540; HGNC:11205; SP1; Sp1 transcription factor; Sp1-1; specificity protein 1; trans-acting transcription factor 1; transcription factor Sp1; TSFP1 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 20683, 24790, 6667 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide | |
| O89090, P08047, Q01714 | |
| SP1 | |
| A synthesized peptide derived from human SP1(Accession P08047), corresponding to amino acid residues T427-P477. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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