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TDP-43 Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech
Alle ansehen Proteintech ProdukteBeschreibung
Proteintech's 10782-2-AP antibody is a rabbit polyclonal antibody recognizing N-terminal TDP-43. It recognizes the intact 45 kDa protein as well as all post translationally modified and truncated forms in multiple applications. Various forms of TDP-
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
Spezifikation
Spezifikation
| Antigen | TDP-43 |
| Anwendungen | Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin) |
| Klassifikation | Polyclonal |
| Konzentration | 0.31 mg/mL |
| Konjugat | Unconjugated |
| Zusammensetzung | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gen | TARDBP |
| Gen-Zugriffsnummer | Q13148, Q921F2 |
| Gen-Alias | ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43 |
| Gensymbole | tardbp |
| Mehr anzeigen |
Name des Produkts
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