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  5. Tocris Bioscience™ TM2 TEAD inhibitor

Tocris Bioscience™ TM2 TEAD inhibitor
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Artikelnummer. p-200007290
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Menge:
10 mg
50 mg
Packungsgröße:
10 Milligramm
50 Milligramm
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Artikelnummer. 18706075

Marke: Tocris Bioscience™ 7917/10

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Beschreibung

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.
TRUSTED_SUSTAINABILITY

Spezifikation

Chemischer Name oder Material 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
CAS 1008768-41-9
Menge 10 mg
Ziel YAP1
Summenformel C26H33N3O3
Reinheit 0.98
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