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  6. Invitrogen™ TNF alpha Monoclonal Antibody (TN3-19.12), eBioscience™, Invitrogen™

Invitrogen™ TNF alpha Monoclonal Antibody (TN3-19.12), eBioscience™, Invitrogen™

Artikelnummer. p-7069582
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Menge:
50 μg
500 μg
Packungsgröße:
50 Mikrogramm
500 Mikrogramm
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15278077 50 μg 50 Mikrogramm
15288077 500 μg 500 Mikrogramm
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Artikelnummer. 15278077 Lieferant Invitrogen™ Lieferanten-Nr. 14742381

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Beschreibung

Armenian Hamster Monoclonal Antibody

Description: The TN3-19.12 monoclonal antibody reacts with mouse, rat, and rabbit tumor necrosis factor-alpha (TNF alpha), but not with human TNF alpha. The TN3-19.12 antibody is a neutralizing antibody. Mouse TNF alpha is a 17 kDa factor produced by macrophages, monocytes, neutrophils, CD4+ T cells and NK cells. A 26 kDa form of TNF alpha is expressed as a membrane-bound molecule. TNF alpha is cytolytic and plays an important role in immune regulation. Dimers and trimers of TNF alpha have been observed. Applications Reported: The TN3-19.12 antibody has been reported for use in intracellular staining for flow cytometric analysis, cytokine neutralization, ELISPOT, IVCCA, and ELISA. Fluorochrome conjugated TN3-19.12 is recommended for use in intracellular staining and flow cytometry. Functional Grade purified TN3-19.12, cat. 16-7423, is recommended for use in functional assays. For ELISPOT capture, the alternative clone, 1F3F3D4 (cat No. 16-7325), is recommended. Applications Tested: The TN3-19.12 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of mouse or rat TNF alpha in combination with the biotinylated anti-mouse/rat TNF alpha polyclonal antibody (13-7341) for detection and recombit mouse TNF alpha (14-8321) or rat TNF alpha as the standard. Product 14-8320 is a bioactive protein, but is not recommended for rat TNF alpha ELISA.] A suitable range of concentrations of this antibody for ELISA capture is 1-4 μg/mL.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
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Spezifikation

Antigen TNF alpha
Anwendungen ELISA, Flow Cytometry, Functional Assay, Neutralization
Klassifikation Monoclonal
Klon TN3-19.12
Konzentration 0.5 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 0.09% sodium azide; pH 7.2
Gen Tnf
Gen-Zugriffsnummer P06804, P16599
Gen-Alias APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF α; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFα; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Gensymbole Tnf
Wirtsspezies Armenian Hamster
Reinigungsverfahren Affinity chromatography
Menge 50 μg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 21926, 24835
Zielspezies Mouse, Rat
Inhalt und Lagerung 4°C
Produkttyp Antibody
Form Liquid
Isotype IgG
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For Research Use Only.

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