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PeproTech TNF alpha Polyclonal Antibody, PeproTech®, Invitrogen™
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Artikelnummer. 17803363
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1 mg
100 μg
50 μg
Packungsgröße:
1 Milligramm
100 Mikrogramm
50 Mikrogramm
Artikelnummer. Menge unitSize
17803363 50 μg 50 Mikrogramm
17873733 100 μg 100 Mikrogramm
17823433 1 mg 1 Milligramm
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Artikelnummer. 17803363

Marke: PeproTech 500P6450UG

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Beschreibung

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Murine TNF-alpha. Anti-Murine TNF-alpha-specific antibody was purified by affinity chromatography employing an immobilized Murine TNF-alpha matrix. Sandwich ELISA: To detect Murine TNF-alpha by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Murine TNF-alpha (500-P64Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Murine TNF-alpha. Western Blot: To detect Murine TNF-alpha by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Murine TNF-alpha is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
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Spezifikation

Antigen TNF alpha
Anwendungen ELISA, Western Blot
Klassifikation Polyclonal
Konzentration 0.1-1.0 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with no preservative
Gen Tnf
Gen-Zugriffsnummer P06804
Gen-Alias APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF α; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFα; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Gensymbole Tnf
Wirtsspezies Rabbit
Immunogen E.coli-derived Recombinant Murine TNF-alpha.
Reinigungsverfahren Antigen affinity chromatography
Menge 50 μg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 21926
Zielspezies Mouse
Inhalt und Lagerung -20°C
Produkttyp Antibody
Form Lyophilized
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