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Tyrosinase Antibody (T311 + OCA1/812), Novus Biologicals™
Mouse Monoclonal Antibody
Marke: Novus Biologicals NBP2-44686-0.1MG
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Beschreibung
Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Tyrosinase Monoclonal specifically detects Tyrosinase in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.
Spezifikation
| Tyrosinase | |
| Monoclonal | |
| 0.2mg/mL | |
| Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 1 - 2 ug/ml | |
| CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA) | |
| Mouse | |
| 75 kDa | |
| 0.1 mg | |
| Lipid and Metabolism | |
| 7299 | |
| Human | |
| Purified |
| Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence | |
| T311 + OCA1/812 | |
| Unconjugated | |
| 10mM PBS and 0.05% BSA with 0.05% Sodium Azide | |
| TYR | |
| Recombinant tyrosinase protein (T311); Recombinant human TYR protein (OCA1/812) | |
| Protein A or G purified | |
| RUO | |
| Primary | |
| Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas. | |
| Store at 4C. | |
| IgG |
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