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Tocris Bioscience™ VCP 171
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Artikelnummer. 18779916
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50 mg
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10 Milligramm
50 Milligramm
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Artikelnummer. 18779916 Lieferant Tocris Bioscience™ Lieferanten-Nr. 6261/10

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Beschreibung

Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

VCP 171 is an adenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5.65, binding cooperativity with NECA 0.68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor-mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve-injury model of neuropathic pain.
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Spezifikation

Chemischer Name oder Material [2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone
CAS 1018830-99-3
Menge 10 mg
Ziel Adenosine A1 Receptor Modulators
Summenformel C18H12F3NOS
Reinheit 0.98
Produkttitel
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