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ACROBiosystems Human IL-17A&IL-17F Heterodimer Protein, His Tag&Strep II Tag
Marke: ACROBiosystems ILF-H52WF-20UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Human IL-17A&IL-17F Heterodimer Protein, His Tag&Strep II Tag, produced by co-expression of IL-17A and IL-17F, has a calculated MW of 17.0 kDa (IL-17A) and 18.4 kDa (IL-17F). Subunit IL-17A is fused with a polyhistidine tag at the N-terminus and subunit ISpezifikation
| NP_002181.1 (IL-17 A) and NP_443104.1 (IL-17 F) | |
| 20 µg | |
| Gly 24 - Ala 155 (IL-17 A) and Arg 31 - Gln 163 (IL-17 F) | |
| IL-17 A,Interleukin-17 A,CTLA-8,IL-17,IL-17 F,Interleukin-17 F,Cytokine ML-1 | |
| Unconjugated | |
| His Tag and Strep Tag | |
| Less than 1.0 EU / µg by the LAL method. | |
| Powder | |
| >95% as determined by reduced SDS-PAGE |
| 17.0 kDa (IL-17 A) and 18.4 kDa (IL-17 F) | |
| Human IL-17 A&IL-17; F Heterodimer Protein, His Tag&Strep; II Tag (ILF-H52WF) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Ala 155 (IL-17 A) and Arg 31 - Gln 163 (IL-17 F) (Accession # Q16552-1 (IL-17 A) and Q96PD4-1 (IL-17 F)). Two sequential affinity purification steps were used to ensure exact 1:1 molar ratio of IL17A&IL17F; heterodimer. | |
| -20°C | |
| IL-17 A and IL-17 F | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Cytokines and Growth Factors |