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ACROBiosystems Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, His Tag&Tag Free
Marke: ACROBiosystems IT1-H52W8-100UG
Weitere Details : Netto-Gewicht : 0.01800kg
Beschreibung
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA7X2B and ITGB1, has a calculated MW of 116.5 kDa (ITGA7X2B) and 83.7 kDa (ITGB1). Subunit ITGA7X2B is fused with an acidic tail at the C-terminus and followed bySpezifikation
| NP_002197.2 (ITGA7X2B) and NP_002202.2 (ITGB1) | |
| 100 μg | |
| Phe 34 - Trp 1038 (ITGA7X2B) and Gln 21 - Asp 728 (ITGB1) | |
| Integrin isoform alpha-7 x 2 B beta 1,ITGA7 x 2 BB1,ITGA7 x 2 BandITGB1 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 116.5 kDa (ITGA7 x 2 B) and 83.7 kDa (ITGB1) | |
| Human ITGA7 x 2 B&ITGB1; Heterodimer Protein, His Tag&Tag; Free (IT1-H52W8) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Trp 1038 (ITGA7 x 2 B) and Gln 21 - Asp 728 (ITGB1) (Accession # Q13683-7 (ITGA7 x 2 B) and P05556-1 (ITGB1)). | |
| -20°C | |
| Integrin isoform alpha-7 x 2 B beta 1 | |
| Human | |
| 50 mM Tris, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |