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ACROBiosystems Human Gremlin / GREM1 Protein, His Tag
Brand: ACROBiosystems GR1-H52H3-100UG
Additional Details : Netto-Gewicht : 0.00001kg
Description
Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.2 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| NP_037504 | |
| 100 μg | |
| Lys 25 - Asp 184 | |
| GREM1,CKTSF1B1,DAND2,DRM,PIG2 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 20.2 kDa | |
| Human Gremlin, His Tag (GR1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Lys 25 - Asp 184 (Accession # NP_037504). | |
| -20°C | |
| Gremlin | |
| Human | |
| PBS, pH7.4 with 1 mM EDTA | |
| HEK293 | |
| Cytokines and Growth Factors |