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ACROBiosystems Human HMGB1 Protein, His Tag
Marke: ACROBiosystems HM1-H5220-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.8 kDa. The protein migrates as 32 kDa and 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_002119.1 | |
100 μg | |
Met 1 - Glu 215 | |
HMGB1,HMG1,HMG3,SBP-1 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |
26.8 kDa | |
Human HMGB1, His Tag (HM1-H5220) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Glu 215 (Accession # P09429-1). | |
-20°C | |
HMGB1 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Bio-Markers and CD Antigens |