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ACROBiosystems Human CD30 / TNFRSF8 Protein, Llama IgG2b Fc Tag, low endotoxin
low endotoxin
Marke: ACROBiosystems TN8-H5250-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 66.3 kDa. The protein migrates as 95-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_001234.2 | |
| 100 μg | |
| Phe 19 - Lys 379 | |
| TNFRSF8,CD30,D1S166E,Ki-1 | |
| Unconjugated | |
| Llama IgG Fc Tag | |
| Less than 0.01 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 66.3 kDa | |
| Human CD30, Llama IgG2b Fc Tag, low endotoxin (TN8-H5250) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Lys 379 (Accession # NP_001234.2). | |
| -20°C | |
| CD30 | |
| Human | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Immune Checkpoint Proteins |