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ACROBiosystems Rhesus macaque Glypican 2 / GPC2 Protein, His Tag
Marke: ACROBiosystems GP2-R52H9-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.9 kDa. The protein migrates as 55-95 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.Spezifikation
| XP_001103286 | |
| 100 μg | |
| Ser 24 - Ser 552 | |
| Glypican 2,GPC2 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 59.9 kDa | |
| Rhesus macaque Glypican 2, His Tag (GP2-R52H9) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 552 (Accession # XP_001103286). | |
| -20°C | |
| Glypican 2 | |
| Rhesus Macaque | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |