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ABCD4 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA530140
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
Recommended positive controls: Raji. Predicted reactivity: Mouse (92%), Rat (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1-4 that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter. A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage. ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD. The peroxisomal membrane comprises two quantitatively major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors. ABCD1 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol.Spezifikation
ABCD4 | |
Polyclonal | |
Unconjugated | |
ABCD4 | |
69 kDa peroxisomal ABC-transporter; ABC41; ABCD4; ATP binding cassette subfamily D member 4; ATP-binding cassette sub-family D member 4; ATP-binding cassette, subfamily D (ALD), member 4; ATP-binding cassette, sub-family D (ALD), member 4; ATP-binding cassette, sub-family D, member 4; EST352188; MAHCJ; P69r; P70R; P79R; Peroxisomal membrane protein 1-like; Peroxisomal membrane protein 69; peroxisomal membrane protein, 70 kDa-related; PMP69; PMP70-related protein; Pxmp1l; PXMP1-L | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
5826 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
0.89 mg/mL | |
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
O14678 | |
ABCD4 | |
Recombinant fragment corresponding to a region within amino acids 359 and 606 of Human ABCD4 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |