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Caspase-7 Mouse, Unlabeled, Clone: 10-1-62, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 551238

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15896578

  • 308.94 € / 1 Stück
Verfügbar ab: 19-12-2022
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Beschreibung

Beschreibung

The caspase family of cysteine proteases plays a key role in apoptosis and inflammation. Caspases are synthesized as inactive proenzymes containing three domains, that are processed into large and small subunits that associate to form the active enzyme. Processing can occur in apoptotic cells by either transactivation, self-proteolysis, or cleavage by another protease. While caspases share a common structure, there are some differences, such as the preferred substrate specificity. These sequence differences in specificity, as well as the size of the NH2-terminal prodomains can be used to catagorize the caspases into functional groups including, apoptotic initiators (long prodomains), apoptotic executioners′ (short prodomains), and cytokine processors. Caspase-7, along with caspase-3 and -6 are members of the apoptotic executioners group containing short prodomains; caspase-7 is structurally and functionally most similar to caspase-3. Upon induction of apoptosis, pro-caspase-7 (35kDa) is first converted to a 32kDa intermediate, which is further processed into active subunits consisting of 20kDa and 11kDa forms (Swiss-Prot P55210). Active caspase-7 has been shown to cleave the nuclear substrate PARP as well as the sterol regulatory element-binding protein 1 (SREBP-1). In cells undergoing Fas-mediated apoptosis in vivo, active caspase-7 has been shown to translocate from the cytosol to the mitochondrial and microsomal fractions, whereas caspase-3 remains cytosolic. This data supports the hypothesis that similar apoptotic executioners cleave distinct substrates in different cellular compartments. The antibody recognizes human and mouse caspase-7. Full-length recombinant human caspase-7 protein was used as immunogen. The antibody is routinely tested by western blot and immunoprecipitation analysis of Jurkat T cells (please refer to Table I for what forms of caspase-7 are identified in a particular application).

Host Species: Mouse
Clone: 10-1-62
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human caspase-7 full-length recombinant protein

Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

Caspase-7
Monoclonal
0.5mg/mL
Mch3
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C
Western Blot
10/1/1962
Unconjugated
Aqueous buffered solution containing ≤0.09% sodium azide.
Human caspase-7 full-length recombinant protein
50 μg
Cell Biology
Mouse, Human
IgG1 κ
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.