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CD31 Rat anti-Mouse, FITC, Clone: MEC 13.3, BD

Rat Monoclonal Antibody

Marke:  BD Biosciences 561813

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15881359

  • 128.82 € / 1 Stück
Verfügbar ab: 19-12-2022
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Beschreibung

Beschreibung

The MEC13.3 antibody reacts with CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1). CD31 is a 130 kDa integral membrane protein, a member of the immunoglobulin superfamily, that mediates cell-to-cell adhesion. CD31 is expressed constitutively on the surface of adult and embryonic endothelial cells and is also expressed on many peripheral leukocytes and platelets. It has also been detected on bone marrow-derived hematopoietic stem cells and embryonic stem cells. CD31 is involved in the transendothelial emigration of neutrophils, and neutrophil PECAM-1 appears to be down-regulated after extravasation into inflamed tissues. Multiple alternatively spliced isoforms are detected during early post-implantation embryonic development; this alternative splicing is involved in the regulation of ligand specificity. CD38 and vitronectin receptor (αvβ3 integrin, CD51/CD61) are proposed to be ligands for CD31. CD31-mediated endothelial cell-cell interactions are involved in angiogenesis. The MEC13.3 mAb inhibits a variety of in vitro and in vivo functions mediated by CD31.

Spezifikation

Spezifikation

CD31
Monoclonal
0.5mg/mL
PECAM-1
Rat
Affinity Purified
RUO
Mouse
IgG2a κ
Flow Cytometry
MEC 13.3
FITC
Aqueous buffered solution containing ≤0.09% sodium azide.
129/Sv mouse-derived endothelioma cell line tEnd.1
25 μg
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Sonderangebote

Sonderangebote

For Research Use Only.