CD4 Rat anti-Mouse, Alexa Fluor 700, Clone: RM4-5, BD
Rat Monoclonal Antibody
Marke: BD Biosciences 557956
Weitere Details : Netto-Gewicht : 0.01000kg
- Sicherheitsdatenblatt (SDS)
The RM4-5 monoclonal antibody specifically binds to the CD4 (L3T4) differentiation antigen expressed on most thymocytes, subpopulations of mature T lymphocytes (i.e., MHC class II-restricted T cells, including most T helper cells and immunosuppressive regulatory T cells), and a subset of NK-T cells. CD4 has also been reported to be detected on pluripotent hematopoietic stem cells, bone marrow myeloid and B-lymphocyte precursors, intrathymic lymphoid precursors, and a subset of splenic dendritic cells. CD4 has been reported to be expressed on the plasma membrane of mouse egg cells and is involved in adhesion of the egg to MHC class II-bearing sperm. CD4 is an antigen coreceptor on the T-cell surface which interacts with MHC class II molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase lck. Purified RM4-5 mAb has been reported to block the binding of FITC-conjugated anti-mouse CD4 clones GK1.5 and H129.19, but not the RM4-4 clone.
This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
|Cd4; CD4 antigen; L3T4; Ly-4; T-cell surface antigen T4/Leu-3|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Alexa Fluor 700|
|Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.|
|Mouse Thymocytes (BALB/c)|
For Research Use Only.