C1 inhibitor Mouse anti-Human, Clone: 8F3, Invitrogen™

Beschreibung

HYB 288-05-02 is specific for human C1INH. HYB 288-05-02 has been successfully used in ELISA procedures. HYB 288-05-02 reacts strongly with C1-INH. Strong reaction is seen with human serμm/plasma when tested in sandwich ELISA in combination with a polyclonal antibody against C1-INH, and in ELISA with C1-INH coated directly onto the microtiter well. The HYB 288-05-02 immunogen is C1-inhibitor (C1INH) isolated from human plasma. Epitope specificity of HYB 288-05-02 differs from that of HYB 288-02-02. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL

C1-inhibitor (C1INH) functions as a regulator of the activation of the classical complement pathway and of the contact activation system of kinin generation and coagulation. Its primary biologically relevant target proteinases are C1r, C1s, coagulation factors XIa and XIIa, and plasma kallikrein. C1-inhibitor consists of one polypeptide chain and has a molecular mass of ∽104 kDa. Serum concentration has been determined to 180 μg/mL.