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FAK (pY397) (Focal Adhesion Kinase) Mouse anti-Human, Unlabeled, Clone: 14, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 611722

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15896009

  • 451.44 € / 1 Set
Verfügbar ab: 19-12-2022
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Beschreibung

Beschreibung

Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the “Focal Adhesion Targeting” sequence (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation at Tyr-397, and activation of FAK through phosphorylation of Tyr residues (Tyr-576 and Tyr577) in the kinase domain activation loop. For example, cell adhesion to a fibronectin substratum involves concurrent activation of Src and phosphorylation of the FAK activation loop. In addition, phosphorylation of other Tyr residues (Tyr-925, and Tyr-861) creates binding sites for SH2 domains of intracellular signaling molecules such as Src, PI3 kinase, and Grb2. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions is important for FAK activation level, and for FAK interaction with a variety of substrates localized to sites of cell adhesion. Thus, FAK activity is regulated by a complex set of phosphorylation sites, and thisphospho-regulation could be important for cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival.

Host Species: Mouse
Clone: 14
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human FAK (pY397) Peptide

Immunofluorescence, Western Blotting

Spezifikation

Spezifikation

FAK (pY397) (Focal Adhesion Kinase)
Monoclonal
250μg/mL
Focal Adhesion Kinase (pY397)
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
14
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human FAK (pY397) Peptide
50 μg
Cell Biology
Human
IgG1
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.