HIV1 nef Monoclonal Antibody (3E6), Invitrogen™

Beschreibung

This antibody reacts with HIV-1 Nef subtypes A, B and C; BRU, IIIB, LAV and BH10 strains. It has been mapped to amino acids 163-173 (SLLHPMSLHGM – B subtypes consensus). This clone may also be referred to as 3E6 (01-004).

HIV-1 Nef is one of the accessory proteins synthesized in the early stage of AIDS virus reproduction and is abundantly found in infected cells. The name derives from its negative factor thought at the beginning but presently it is remarked as the protein which bears a most distinctive biological characteristic of AIDS virus. The protein interacts directly with the signal transduction protein of the host T cell and works effectively on AIDS infection or on long term survival of the infected cells or induces apoptosis of non-infected cells. It is also involved in the endocytosis and degradation of receptor protein of the cell surface such as CD 4 and MH4, important for AIDS virus infection.