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HIV1 Tat Monoclonal Antibody (N8), Invitrogen™

Mouse Monoclonal Antibody

Marke:  Invitrogen MA171513

Weitere Details : Netto-Gewicht : 0.01000kg

Artikelnummer. 11550352

  • 473.00 € / 100 Mikrogramm
Verfügbar ab: 04-06-2024
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Beschreibung

Beschreibung

This antibody reacts with HIV-1 Tat HXB2, BH10, IIIB and HAN strains. It has been mapped to amino acids 59-67 (PQDSQTHQV – B subtype a.a. consensus). MA1-71513 can be used for chromatin immunoprecipitation (ChIP) analysis of HIV1 Tat. This clone may also be referred to as N8 (Tat N8).

HIV-1 Tat ("e;Trans-Activator of Transcription"e;) consists of 86 to 101 amino acids depending on the subtype. Tat is critical to HIV reproduction by way of compensating for a defect in its genome: the HIV RNA initially has a hairpin-structured portion which prevents full transcription from occurring. However, a small number of RNA transcripts will be made, which allow the Tat protein to be produced. Tat then binds to and phosphorylates cellular factors, eliminating the effect of the hairpin RNA structure and allowing transcription of the HIV RNA. This increases the rate of transcription, providing a positive feedback cycle. The protein is released by infected cells in culture, and is found in the blood of HIV-1 infected patients.
Spezifikation

Spezifikation

HIV1 Tat
Monoclonal
1 mg/mL
PBS with 0.1% sodium azide; pH 7.4
Mouse
Protein G
RUO
Virus
Antibody
IgG2b
ChIP Assay, ELISA, Western Blot
N8
Unconjugated
HIV-1 Tat
Recombinant Tat protein of HIV-1 HAN purified from E. coli
100 μg
Primary
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote