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mGluR1 Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 610965

Weitere Details : Netto-Gewicht : 0.01100kg

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Artikelnummer. 15885729

  • 543.78 € / 1 Set
Verfügbar ab: 23-12-2022
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Beschreibung

Beschreibung

Glutamate is a major excitatory neurotransmitter and functions in multiple roles in the CNS. The functional diversity of glutamate is exemplified by two distinct groups of glutamate receptors: ionotropic and metabotropic. Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. Eight metabotropic glutamate receptors (mGluR1-8) and several Ca2+ sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. However, they exhibit no additional sequence homology to any member of other GPCR families. mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains. The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. mGluR1 activates phospholipase C (PLC), resulting in phosphoinositide turnover and, in turn, Ca2+; mobilization necessary for many signal transduction events.

Immunofluorescence, Western Blotting

Spezifikation

Spezifikation

mGluR1
Monoclonal
250μg/mL
Metabotropic Glutamate Receptor-1
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
20
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Rat mGluR1 aa. 1042-1160
150 μg
Cell Biology
Rat, Mouse
IgG1
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.